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Ul Haq I, Krukiewicz K, Yahya G, et al

Perano SJ, Rayner CK, Kritas S, Horowitz M, Donaghue K, Mpundu-Kaambwa C, et al

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Search strategy A systematic search was conducted across various databases and registers, including MEDLINE (via PubMed), Scopus, Cochrane Central Register, and ClinicalTrials.gov

Taken together, this evidence suggests that the heterogeneity of studies models and the interaction of many adaptive mechanisms might explain the variable results in the recent studies concerning the influence of SGLT2-i treatment on the RAAS, although an activation of intrarenal RAS in chronic treated patients has been excluded (42)