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TGR5 activity appears to not have been lost in type 2 diabetic humans whereby the infusion of CCK, or rectal taurocholate, causes GLP-1 and insulin release via the TGR5 axis in colonic L-cells and pancreatic -cells respectively (341, 342)

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SOURCE: The New York Times , March 4, 2026 Copyright 2026 HealthDay

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2025, doi: 10.1016/j.ajcnut.2025.04.023

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