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Sarcopenic obesity prevalence dropped from 49% to 33% and handgrip strength improved

With regard to RECOVER, this is apparently because trials funded by NIH must use doses that have an established toxicology and pharmacokinetic profile already accepted by FDA

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In pathophysiological situations, as occurs in Zucker obese rats, exendin-4 seems to act as a compensator for the variations in AMPK activity produced either by oscillations in glucose levels or by pathologies such as obesity or episodes of hyperinsulinemia