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N Engl J Med 334:574579 Amori RE, Lau J, Pittas AG (2007) Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
Given that both T1DM and T2DM are associated with reduced beta-cell mass and function, these various studies highlight the therapeutic potential of harnessing alpha-cell GLP-1 production to not only stimulate insulin secretion but also promote beta-cell survival and regeneration

Adults with a BMI of 25 or higher who havent achieved success with diet and exercise alone, and are in overall good health
