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These data can assist clinicians in selecting appropriate medications based on specific adverse reaction profiles of patients

A deeper dive: For more information on what to eat and how to train, see our guide: Age Strong on GLP1s: Preserving Muscle & Bone

Tirzepatide is newer, but interest in its use at lower doses is growing, particularly as head-to-head data comparing the two medications has emerged

It is a targeted treatment that works with your body's existing hormonal pathways

Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)