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Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

Brain cell metabolism was preserved in one trial, and the other found reduced amyloid-beta in extracellular vesicles, but neither trial found that GLP-1 drugs reduced the build-up of amyloid-beta in the brain or helped stave off cognitive decline

Tirzepatide (Mounjaro, ZepBound): This dual-action medication mimics both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP, another naturally occurring hormone), resulting in even greater weight loss for many people

GIP and GLP-1 together create stronger effects on reducing appetite and improving your body's response to insulin, often leading to more weight loss
