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Like ShedRx, they rely on compounded GLP-1s, which are not FDA-approved

Animal studies suggest it is well-tolerated, but human trials are still ongoing

By synthesizing preclinical and clinical data, we elucidate how GLP-1 RAs may modulate key pathological processes in KOA, such as NF-B inhibition, autophagy activation, and macrophage polarization

Wegovy is a specific, FDA-approved brand-name drug product, while compounded semaglutide is a customized medication prepared by a licensed pharmacist in an FDA-registered pharmacy
