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The effects appear to rely on GLP-1Rs located in the NAc shell and lateral septum, supporting the notion of region-specific neuromodulation

ZhangYQuZLuTShaoXCaiMDilimulatiDet al

During the scans, the investigators induced a self-critical rumination state by having participants think about personal failures

A consistent calorie deficit can result in weight loss

Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
