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Approved uses for GLP-1 agonists so far include treating diabetes, obesity and most recently reducing the risk of major cardiovascular events

Within the GLP-1RA group, discontinuing treatment for even 0.5 years was associated with a higher MACE risk compared to continued use

Liraglutide (Saxenda) Liraglutide works through the same GLP-1 pathway but has a different dosing schedule than other options on the market, requiring a daily rather than weekly injection

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These critical modifications confer a slightly higher affinity to the GLP-1 receptor for both peptides, enabling lower concentrations to achieve equivalent receptor occupancy compared to native GLP-1 [13]