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Clinical guidance for switching: No washout period is needed you can transition directly without a gap in therapy Always restart tirzepatide at 2.5mg , regardless of your previous semaglutide dose, to manage GI side effects Expect possible temporary nausea during the transition as your body adjusts to the new mechanism Escalate every 4 weeks from 2.5mg as tolerated Always make this change under the supervision of a licensed provider who can monitor your response FAQs Is tirzepatide stronger than semaglutide for weight loss

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With RETA withdrawal, endpoint analysis revealed that HOMA-IR was restored to just 40% of the Veh group (Supplementary Fig