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First, delayed gastric emptying alters absorption kinetics

The distribution of potential effect modifiers (HbA 1c and body weight at baseline) was deemed sufficiently similar across all treatment comparisons to assume that a network meta-analysis was appropriate (ESM Figs 2 and 3)

Do not discontinue Wegovy without consulting your prescriber, as abrupt cessation may affect your weight management programme

New allergies can theoretically develop at any point, but this appears uncommon with peptide medications

Key highlights Retatrutide is an emerging blockbuster weight loss medication that acts on three receptors (GLP-1, GIP, and glucagon) simultaneously to suppress appetite and promote weight reduction