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All meta-analyses were conducted using a random-effects model irrespective of I value, in accordance with Cochrane Handbook recommendations

10 , e392 (2021)

Our clinical opinion is that reducing portion sizes is important because nausea may be partly related to delayed gastric emptying associated with GLP1RA use

Best Practices for GLP-1 Cold Chain To protect GLP-1 potency and compliance, organisations should: Store in validated fridges and freezers

Saxagliptin is metabolized by CYP3A4/5 into an active metabolite that is approximately half as potent as the parent compound, with terminal halflives of 2.5 and 3.1 h, respectively [97]