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This has important implications for clinical practice and health policy, particularly given cardiovascular disease is the leading cause of death in the UK

The proposed rule formalizes a regulatory position that has already been reflected in enforcement actions since early 2025

[DOI] [PubMed] [Google Scholar] 47.Jastreboff A.M., Aronne L.J., Ahmad N.N., et al

The STOP KNEE-OA trial is ongoing: 72 weeks of tirzepatide versus placebo in adults with knee osteoarthritis and obesity, with a reduction in the need for knee replacement as the main outcome

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