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Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)

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Optimized Ergonomics: With a low pressing forcerequiring less than 8N for 60-unit dosesthe device ensures ease of use for patients with limited manual dexterity

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