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Description
( PMID: 33767808
The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor
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MariTide Name: Maridebart cafraglutide (MariTide, formerly AMG 133) Manufacturer: Amgen Current stage: US phase III trial currently underway (MARITIME, NCT06858839) Takeaway: The dual agonist/antagonist action of MariTide could promise higher weight loss with fewer side effects, with dosing at less frequent intervals but more studies are needed
Sex-specific signaling, while potentially advantageous, complicates trial design and regulatory evaluation
