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Patient-derived human islets from male and female cadaveric donors were 3D-cultured in solubilised extracellular matrix gel in co-culture with the same donor PBMCs, and incubated with cytokines (IL-1, TNF-, IFN-) for 2448 h in the presence of vehicle or increasing concentrations of the CB1R blocker JD-5037

Moreover, the addition of finerenone to this combination therapy could potentially provide stronger cardiorenal protective benefits

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It potentiates the glucose-induced secretion of insulin from pancreatic beta cells, increases insulin ...