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Megalin is expressed along the apical aspect of proximal tubules, where it is responsible for hepatocyte-derived AGT reabsorption and its homeostasis in kidney

Besides the 10 thermostabilizing mutations that reported previously 26,27 , E387 7.42b D was introduced to mimic the identified interaction in the GCGR-NNC1702 complex structure 9

10.1038/s41591-024-03355-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 68.Cui SS, Feng XB, Zhang BH, Xia ZY, Zhan LY (2020) Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation

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