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As of June 2025, the FDA removed both semaglutide and tirzepatide from its drug shortage list, a move that limits when and how pharmacies can legally compound these medications

Zepbound, Semaglutide GLP-1, and Wegovy are all medications used for weight management, but Semaglutide GLP-1 is considered more effective overall

There is usually no downtime or visible swelling or bruising, and patients can exercise, apply makeup, and generally go on with their normal day afterward

Stopping GLP-1 therapy typically results in reversal of therapeutic effects, including deterioration in blood glucose control and weight regain within weeks to months

Looking to the future of what this means for GLP-1 deal making, the central message is that obesity is still very much a hot bed as there is need to invest in emerging modalities that can be combined/co-administered with GLP-1s and mitigate risks/target the residual unmet need associated with GLP-1s including the serious side effects such as nausea, vomiting, weight regain and excessive muscle loss