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Author contributions UK: Methodology, Data curation, Investigation, Software, Conceptualization, Writing review & editing, Visualization, Resources, Writing original draft, Formal analysis

Some individuals plateau at lower-than-typical doses due to genetic variations that affect drug metabolism and clearance rates

This article reviews and summarizes the current preclinical/clinical treatments for PD, their efficacies, and the advantages/disadvantages of various stem cells, including pluripotent and multipotent stem cells, to provide a detailed overview of how these cells can be applied in the treatment of PD, as well as the challenges and bottlenecks that need to be overcome in future translational studies