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Administer semaglutide subcutaneously in the abdomen, thigh, or upper arm, rotating sites weekly to minimize injection site reactions such as redness, itching, or lipohypertrophy

The public health burden of obesity may influence coverage decisions as payers recognize the value of effective treatment

These gastrointestinal side effects typically improve within the first 2 months of treatment as physiological adaptation occurs. Expected Timeline: Weeks 1-4 : Peak intensity, especially after starting medication or dose increases Weeks 4-8 : Gradual improvement as the body adjusts to delayed gastric emptying Week 8+: 80% of cases show significant resolution Persistent cases : May require dose adjustments or alternative treatments Sulfur burps are normal on Wegovy and other GLP-1 medications as the digestive system adapts to slower gastric motility

(Watch for more details on this.) Physicians must also submit a prescription and prior authorization request to the central processor when required

Other treatment options might possibly include gastric pacemakers, injections of Botox, or endoscopic pyloromyotomy (G-POEM)