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Description
Studies in mice demonstrated that liraglutide-induced C-cell proliferation was dependent on the GLP-1 receptor and that liraglutide did not cause activation of the REarranged during Transfection (RET) proto-oncogene in thyroid C-cells

But they have not been tested in the way that standard doses have been tested

Yes, many IBS patients take semaglutide successfully

10.1124/dmd.114.059121 [DOI] [PubMed] [Google Scholar] Khalil F., Ler S
These sensations usually peak around day 2-3 and improve significantly by day 5-7
