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As a member of the transforming growth factor- (TGF-) superfamily, GDF-8 controls muscle mass by suppressing the proliferation of muscle cells, maintaining muscle volume within a stable range

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At study entry, 38% of the patients were taking sodium glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide-1 receptor agonists (GLP-1 RAs), medications for diabetes that have been shown to have beneficial effects on heart disease, including reducing heart failure, heart attacks and strokes

At ObesityWeek in 2019, bimagrumab for obesity made a big splash and then it went quiet