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The REWIND trial with dulaglutide included many patients without established ASCVD and demonstrated a consistent reduction in MACE, supporting a role in primary prevention, although the effect size was modest

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The glucagon part raises a theoretical flag about insulin sensitivity and liver sugar, but again, the published data doesnt show meaningful high blood sugar

Maintenance, Muscle, and Long-Term Metabolic Health GLP-1 weight loss can be life-changing for appropriate patients

[DOI] [PMC free article] [PubMed] [Google Scholar] 290.De, S., et al., Unraveling the Ties: Type 2 Diabetes and Parkinsons Disease - A Nano-Based Targeted Drug Delivery Approach