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Clinical trials of semaglutide show participants spontaneously reduce calorie intake by an average of 500800 calories daily, partly because high-carb foods like bread become less appealing

In obesity clinical trials, patients achieved approximately 15-21% weight loss over 72 weeks, with somewhat smaller weight reductions typically seen in diabetes trials

Baseline metabolic health, insulin resistance, dietary consistency, physical activity, sleep quality, and stress levels all influence weight loss outcomes

For patients with high risk of developing NAION (e.g., those with diabetes, hypertension) who are taking GLP-1RAs, ophthalmologists may increase vigilance, she said

Based on this information, she may prescribe Semaglutide or Tirzepatide