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In our experience, the rate at which patients are willing and able to stay on treatment depends less on the medication itself than on how their clinical team responds to symptoms

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However, due to their efficacy in inducing body-weight loss, extensive evidence with high doses of GLP-1R agonists have demonstrated clinically relevant and sustained effects on body weight in obesity [26]

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Glucagon is usually thought of as a glucose- raising hormone, but in the context of simultaneous GLP-1/GIP agonism the net effect studied in trials was increased energy expenditure alongside strong glycemic control a combination that appears to explain the outsized weight effect observed in the research