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All authors contributed to the conception, interpretation, writing the manuscript, figure outline/design, met criteria for authorship and approved the final manuscript

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A particular alteration involves lysosomal dysfunction, which hinders the degradation of structurally damaged mitochondria, leading to cellular toxicity ( In AD, dysfunctional mitochondria accumulate and exacerbate lysosomal degradation bottlenecks

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The AUC 024h,sema,Day10 (primary endpoint) was calculated using the linear trapezoidal method based on observed semaglutide concentrations and actual measurement times