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Description
GLP-1 medications, also known as GLP-1 receptor agonists, mimic the action of natural GLP-1 in the body
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In a phase 2, double-blind, placebo-controlled trial of retatrutide vs placebo (NCT04881760), adults with obesity or with overweight and obesity-related complications but without diabetes who were treated with retatrutide achieved a mean weight reduction of up to 17.5 % at 24 weeks (primary endpoint) and up to 24.2 % at 48 weeks in the 12 mg group
doi: 10.1172/JCI117004 46 van HeerebeekLHamdaniNHandokoMLFalcao-PiresIMustersRJKupreishviliKet al
