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As a practical clinical rule of thumb, this is often described as minimal or no weight changetypically less than 1% of body weightover a consecutive four-week period

Extreme heat or cold can lead to molecular degradation, potentially altering the drug's chemical composition and reducing its therapeutic efficacy

We applied consistent inclusion and exclusion criteria throughout all analyses and conducted multiple sensitivity assessments, including BMI-stratified subgroup analyses and clinical characteristic stratification, to verify the robustness of our findings across different patient populations

Months two through six build the visible results

Losing weight and feeling great