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In a large retrospective cohort study, GLP-1RAs significantly improve metabolic outcomes in individuals with MASLD, it can reduce major adverse cardiovascular events, all-cause mortality, and hospitalizations due to heart failure among individuals diagnosed with type 2 diabetes ( 2.3 Crosstalk between GLP-1 and and the gut microbiome 2.3.1 GLP-1 modulates the gut microbiota Emerging evidence indicates a bidirectional regulatory relationship between GLP-1RAs and the gut microbiota (Zhang et al., 2018

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Wegovy continues escalating) Months 46 (Wegovy only): 1.7 mg 2.4 mg weekly maintenance dose Clinical data from the STEP 5 trial (2-year follow-up) showed that the majority of participants tolerated semaglutide well in the long term, with fewer than 4% discontinuing due to side effects
