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Apart from reward, this initial AUD phase is influenced by the motivation to consume alcohol, which is another factor controlled by GLP-1R in male rats

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Think of it like this: GLP-1 is one musician playing a song GIP is a second musician playing a different instrument Tirzepatide combines both musicians into one band the result is louder, stronger, and more effective When both hormones are activated together, the insulin response is significantly more powerful than either hormone alone