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Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1), that targets areas of the brain that regulate appetite and food intake and also enhances insulin secretion from the pancreas and regulates blood sugar

In TriNetX, after defining the cohorts, index dates, outcomes, and relevant covariates that could serve as potential confounders, the platform creates a covariate matrix by capturing each variable for individual patientstypically within one year before the index date

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30,31,7577 This may be considered evidence that these drugs could pass through the BBB and activate the neurons in these nuclei