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The C-terminal of hormone binds to the extracellular domain, while the N-terminal interacts with the transmembrane domain of the receptor (43)

Women may tolerate slightly more than men

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Severe dehydration can lead to dizziness, weakness, kidney injury, low blood pressure, electrolyte imbalance, cardiac complications, and hospitalization requiring intravenous fluids or nutritional support

44 Excessive ROS can inhibit IRS1 activation by activating inflammation-related protein kinase C, inhibitor kappa B kinase (IKK), c-Jun N-terminal kinase (JNK), and p38 MAPK, thereby aggravating IR, 45 creating a vicious cycle