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FIGURE 7 However, another peptide, codenamed SR18 (H-Igl-E-Aib-TFTSDLSDHYESKA-CONH 2 ), which contained several amino acids similar to those found on the GLP-1 and demonstrated a docking orientation similar to the GLP-1 with a binding energy score of 272.14, was rationally shortlisted for further studies as a first-generation GLP-1RA over the top-ranked peptide (H-Igl-E-Aib-AWMTSIISTMWAKH-CONH 2 )

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Ideal candidates include those with a BMI of 30 or greater, or those at a BMI of 27 or above with conditions such as hypertension or high cholesterol

In addition, metformin, by an unknown mechanism, may enhance GLP-1 response

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