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[1] [5] Strategic dietary modifications can help reduce the severity and duration of these symptoms

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Percentages will not sum to 100.0% because (1) each exposure may result in 0, 1, or more clinical effects, and (2) not all clinical effects are listed in the table c Row percentages may not sum to 100.0% due to rounding error Trend Analysis The rate of cases per one million US population increased from 1.16 in 2017 to 3.49 in 2021 and then rapidly increased by 80.9% to 6.32 in 2022

Month 3: Reaching the 1.0 mg Threshold The 1.0 mg dose marks the transition into higher therapeutic levels

Notes: * 2-Aminoisobutyric acid ** excluding other moieties (e.g., PEG) Key Sources: 2: 4: 5: Comments and opinions expressed by interviewees are their own and do not represent or reflect the opinions, policies, or positions of DeciBio Consulting or have its endorsement