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The drug is also used off-label for weight loss, although it has not received FDA approval for this use

doi: 10.1038/s41467-023-37214-4

However, GLP-1 has a very short half-life of about 1.5 minutes and is rapidly suppressed by an enzyme called dipeptidyl peptidase-4 (DPP-4)

This approach delivers superior weight loss velocity compared to single agents in clinical trials while maintaining the same fixed monthly cost

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