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Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrm-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL

Moreover, the anatomy of the PPG-neuron projections is ideally situated to provide interoceptive information from the hindbrain to the limbic areas mediating the responses to stress (111, 112)

Phase 3 trials, which involve larger and more diverse populations over longer durations, are currently underway (see ClinicalTrials.gov for registered studies) and will provide more robust evidence before any regulatory submission can be considered

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Drossman DA, Camilleri M, Mayer EA, Whitehead WE