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[11] [12] Those who believe they may benefit from emerging treatments like retatrutide in the future should discuss this with their GP or a specialist, who can advise on clinical trial eligibility or monitor developments in licensing

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The clinical significance of this interaction is highest with antineoplastic doses of methotrexate, but if a patient on antirheumatic doses of methotrexate can receive an alternative class to PPIs, it is the safest option to avoid any risk of methotrexate toxicity and delayed methotrexate elimination