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Heterogeneity was assessed using the I 2 statistic and Cochrans Q test

Regarding cardiovascular outcomes, the EXSCEL trial showed that exenatide extended-release was noninferior but not superior to placebo for major adverse cardiovascular events

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These findings underscore the complex interplay between sex, diet, and GE2 efficacy in middle age, emphasizing the need for tailored therapeutic strategies

SEMA (GLP-1) Research Compound is a high-purity synthetic GLP-1 analogue used extensively in metabolic, glucose-regulation, and peptide-signalling studies