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That lipidation is what enables once-weekly dosing by extending the molecule's half-life from minutes to approximately seven days, but it also introduces manufacturing complexity that goes far beyond the peptide backbone itself

Diabetes Obes Metab 22(12):25042506

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Increasing medication prescribing in primary care offices and settings could help increase access, Gregory said, but there is still a lot of work to be done in figuring out how to reduce these barriers to care and how to best deliver treatment in the most cost-effective, safe and effective ways