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The freeze-thaw cycle is catastrophic for most reconstituted peptides, leading to aggregation and a significant loss of biological activity

Importantly, the GLP-1 response to dietary fat is vastly reduced not only in GPR40 KO animals but also in GPR119 KO mice, and agonists for the Gq-coupled GPR40 act in synergy with the Gs-coupled GPR119 to robustly stimulate GLP-1 [286,300]

This treatment significantly reduced levels of pro-inflammatory cytokines such as TNF- and IL-6, decreased DNA fragmentation and apoptosis, and mitigated oxidative and nitrosative stress caused by streptozotocin (93)

The emerging research is clear enough to justify a more thoughtful approach

Excellent work