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Plateaus Plateaus are one of the most common reasons patients become discouraged and discontinue treatment

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In this post, I take a deep dive into EVOKE and EVOKE+, examining trial design, endpoints, effect sizes, and interpretability

The landmark LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial, which enrolled 9340 individuals with T2D at high CV risk, demonstrated that liraglutide significantly reduced the incidence of major adverse cardiovascular events (MACE) compared with placebo over a median follow-up of 3.8 years (Hazard Ratio [HR]: 0.87