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For leaner individuals, the subcutaneous layer may only be 5-8mm, which means a 45-degree angle and skin pinching become essential to avoid hitting the muscle
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The pathomechanisms of obesity-associated MASLD include lipotoxicity, inflammation, fibrogenesis, and carcinogenic risk [39], suggesting that combating obesity is a major objective in treating MASLD
A 27-gauge needle is the most commonly recommended
however, GIP sensitivity can be restored after improvement of glycemic control
