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Cagrilintide is also dosed in mg but at much lower doses (0.25-2.4 mg range)

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Based on cell culture studies, retatrutide shows lower potency than the bodys own signaling molecules at the GCGR and GLP-1R roughly 0.3 and 0.4 times as active, respectively while showing greater potency at the GIPR, at approximately 8.9 times the activity of the natural ligand

A targeted 2,000 patients will be randomised 2:1 to elafibranor 120 mg daily vs