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Description
This is a novel, investigational tri-agonist peptide that acts on the GIP, GLP-1, and glucagon receptors

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Researchers investigate how these pathways may interact in controlled models involving metabolic signalling, energy regulation and peptide pharmacology

By inhibiting osteoblast differentiation of VSMCs, GLP-1RAs can ameliorate phosphate-induced vascular calcification, which is mediated by the AMPK/mTOR pathway or AMPK/receptor activator of nuclear factor kappa B ligand (RANKL), as occurs in the osteoblast differentiation of VSMCs [128, 129]

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