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Description
GLP-1 stimulates insulin secretion, inhibits glucagon release, and, perhaps most notably, suppresses appetite and reduces food intake [14]

gastrointestinal adverse events (nausea, diarrhea, vomiting) were common but generally mild to moderate

Availability and Prescribing Status in the UK Neither compound is routinely available in the UK: tesamorelin requires named-patient importation as an unlicensed medicine, and retatrutide is only accessible through regulated clinical trials

Store it in a middle shelf toward the back

The authors conclude that these findings highlight the therapeutic potential of selectively targeting the GLP-1 receptorTRPM5 signalling axis, paving the way for next-generation incretin-based therapies for type 2 diabetes
