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The evolving story of incretins (GIP and GLP -1) in metabolic and cardiovascular disease: A pathophysiological update

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Although these recent studies appear somewhat conflicting and contentious 28,31,32 , as more studies continue to map out the neuronal gutbrain signaling axis, they could ultimately lead to very precise therapeutics directly targeting specific neural subgroups within vagal afferents to treat specific physiological mechanisms, such as controlling food intake versus intestinal motility

In clinical trials, there were no differences observed in the efficacy of Mounjaro in elderly populations

This suggests that, within the studied population, there were no notable differences in the occurrence of suicidal and self-injurious AEs between the two genders that would raise concerns requiring further investigation
