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"The side effects for metformin are usually milder, and they resolve with time or by eating some food," Horn says

This framing is uncomfortable for many people who view medication as something you take temporarily until a problem resolves, but it aligns with the biological reality of obesity as a chronic disease with chronic neurohormonal underpinnings

Most are mild and temporary, while serious complications are rare

Influence of environmental temperature on risk of gestational diabetes

Semaglutide is a long-term medication for chronic weight management
