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The fatigue typically stems from three sources: reduced caloric intake (you are eating less, which means less fuel), GI discomfort (nausea and stomach issues are exhausting), and metabolic adjustment as your body adapts to new hormone signaling patterns

Goldner MG, Knatterud GL, Prout TE

The 2024-2025 research showing bone loss on GLP-1 therapy identified those losses by comparing pre-treatment and post-treatment DXA measurements

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