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Some studies have examined whether berberine might influence GLP-1 secretion through effects on the gut microbiome and intestinal cells
Several studies suggest that similar to lipids, reductions in food intake via intestinal protein in rodents are due to CCK release and subsequent activation of VANs, as (1) intestinal protein infusion increases CCK in rodents and humans 188,189
In patients with a greater burden of vascular dysfunction, fibrosis, or cardiometabolic comorbidities, adjunctive treatment with nonsteroidal mineralocorticoid receptor antagonists (MRAs), RAAS pathway inhibitors, and other metabolically oriented agents may also be considered
One of the most promising breakthroughs is Semaglutide, an FDA-approved medication thats redefining weight management
However, individual responses vary considerably, and some patients may experience more pronounced effects than others
