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Phase 3 ACHIEVE-1 trial results for orforglipron, as discussed by Rosenstock and colleagues, demonstrated that this once-daily oral small molecule GLP-1 achieved statistically significant reductions in HbA1c (1.3% to 1.6% from a baseline of 8.0%) compared to placebo in adults with type 2 diabetes

GLP-1 medications are prescribed to lower blood sugar levels in people with type 2 diabetes

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1.6 to 2.0 grams of protein per kilogram of body weight, per day

2 Essentially, the idea is that by stimulating these receptors, certain bitter compounds may support the bodys natural satiety mechanisms